Monkeypox Vaccine: 7 Essential Benefits for Those Who Should Get Vaccinated
August 20, 2024 | by Rehana Sadia

Monkeypox Vaccine: Who Should Get It and Why?
Introduction
In recent years, the world has been reminded of the unpredictable nature of viral outbreaks. Among these emerging threats is monkeypox, a viral disease closely related to smallpox. Although less severe than its cousin, monkeypox has garnered global attention due to its rapid spread and the potential for severe health consequences. This has raised an important question: who should consider getting the monkeypox vaccine, and why?
Understanding Monkeypox
Before diving into the specifics of the monkeypox vaccine, it’s crucial to understand what monkeypox is. Monkeypox is a zoonotic virus, meaning it can be transmitted from animals to humans. The virus was first identified in 1958 in monkeys, which is how it got its name. However, rodents are believed to be the primary carriers. Human cases were first reported in the Democratic Republic of Congo in 1970, and since then, outbreaks have occurred sporadically across Central and West Africa.
The symptoms of monkeypox are similar to, but milder than, those of smallpox. They include fever, headache, muscle aches, and a characteristic rash that can spread across the body. While most cases resolve without treatment, monkeypox can be severe, especially in children, pregnant women, and individuals with compromised immune systems.
The Monkeypox Vaccine: An Overview
Given the potential severity of monkeypox, vaccination has become a crucial tool in preventing its spread. The monkeypox vaccine, also known as the smallpox vaccine, is derived from the vaccinia virus, a virus closely related to both smallpox and monkeypox. The vaccine is effective in preventing monkeypox because of the close relationship between the viruses.
There are two main types of vaccines available: ACAM2000 and JYNNEOS (also known as Imvamune or Imvanex). ACAM2000 is a live virus vaccine, meaning it contains a live but weakened form of the vaccinia virus. JYNNEOS, on the other hand, is a non-replicating vaccine, which means it contains a modified form of the virus that cannot reproduce in the body. Both vaccines have been shown to be effective in preventing monkeypox.
Who Should Get the Monkeypox Vaccine?

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A healthcare provider donning a pair of green latex gloves in order to protect herself during her subsequent interaction her next patient. Original image sourced from US Government department: Public Health Image Library, Centers for Disease Control and Prevention. Under US law this image is copyright free, please credit the government department whenever you can.
Determining who should receive the monkeypox vaccine depends on several factors, including exposure risk, underlying health conditions, and the likelihood of severe outcomes if infected. Let’s explore the groups that are most likely to benefit from the monkeypox vaccine.
1. Healthcare Workers
Healthcare workers are often on the front lines when it comes to infectious diseases, and this is no different with monkeypox. Those who work in hospitals, clinics, or laboratories where they may come into contact with the virus are at higher risk of exposure. For these individuals, the monkeypox vaccine is strongly recommended, as it provides a vital layer of protection against potential infection.
2. Individuals in Endemic Areas
People living in regions where monkeypox is endemic—primarily Central and West Africa—are at a higher risk of contracting the virus. In these areas, the monkeypox vaccine is an important preventive measure. Vaccination can help reduce the spread of the virus within communities and protect individuals from severe disease.
3. Travelers to Endemic Regions
Travelers who plan to visit areas where monkeypox is common should also consider getting vaccinated. This is particularly important for those who may have close contact with animals or individuals who could be infected. The monkeypox vaccine can provide peace of mind and protection during travel to regions with known outbreaks.
4. Immunocompromised Individuals
People with weakened immune systems, such as those with HIV/AIDS, cancer, or those taking immunosuppressive medications, are at higher risk of severe outcomes if they contract monkeypox. For these individuals, the monkeypox vaccine is a critical preventive measure. It can help reduce the risk of severe illness and complications associated with the virus.
5. Laboratory Workers Handling Orthopoxviruses
Laboratory workers who handle orthopoxviruses, the family of viruses that includes monkeypox, are at increased risk of exposure. The monkeypox vaccine is recommended for these individuals to protect them from accidental infection in the laboratory setting.
6. Pregnant Women in High-Risk Areas
Pregnant women are generally at higher risk of complications from viral infections, and monkeypox is no exception. For pregnant women living in or traveling to high-risk areas, the monkeypox vaccine can provide crucial protection. However, the decision to vaccinate should be made in consultation with a healthcare provider, considering the potential risks and benefits.
7. Close Contacts of Infected Individuals
In the event of a monkeypox outbreak, close contacts of infected individuals may be advised to receive the monkeypox vaccine as a preventive measure. This includes family members, caregivers, and anyone who has had direct contact with an infected person. The vaccine can help prevent the spread of the virus within households and communities.
Why Is the Monkeypox Vaccine Important?
The importance of the monkeypox vaccine cannot be overstated, especially in the context of preventing the spread of the virus and protecting vulnerable populations. Here are some key reasons why the monkeypox vaccine is vital:
1. Preventing Outbreaks
One of the primary goals of the monkeypox vaccine is to prevent outbreaks. Vaccinating high-risk individuals and populations can help curb the spread of the virus and reduce the likelihood of large-scale outbreaks. This is particularly important in regions where monkeypox is endemic or where there is a high risk of introduction.
2. Protecting Vulnerable Populations
Certain groups, such as immunocompromised individuals, children, and pregnant women, are at higher risk of severe outcomes if they contract monkeypox. The monkeypox vaccine provides these vulnerable populations with essential protection, reducing the risk of severe illness and complications.
3. Reducing the Burden on Healthcare Systems
In the event of a monkeypox outbreak, healthcare systems can become overwhelmed with patients requiring treatment and care. By vaccinating high-risk individuals, the burden on healthcare systems can be reduced, allowing them to focus on providing care to those who need it most.
4. Providing Peace of Mind
For individuals who live in or travel to areas with known monkeypox outbreaks, the vaccine can provide peace of mind. Knowing that they are protected against the virus can alleviate anxiety and allow them to focus on their daily lives or enjoy their travels without constant worry.
Potential Side Effects of the Monkeypox Vaccine
Like any vaccine, the monkeypox vaccine can cause side effects. Most side effects are mild and resolve on their own within a few days. Common side effects of the monkeypox vaccine include:
- Soreness or redness at the injection site
- Fever
- Fatigue
- Headache
- Muscle aches
In rare cases, more serious side effects can occur, such as allergic reactions or complications related to the live virus in the ACAM2000 vaccine. It’s important to discuss any concerns with a healthcare provider before getting vaccinated.
Conclusion
The monkeypox vaccine plays a crucial role in preventing the spread of this potentially serious virus. While not everyone needs the monkeypox vaccine, certain groups—such as healthcare workers, individuals in endemic areas, travelers, immunocompromised individuals, and others at high risk—should strongly consider getting vaccinated. The vaccine provides essential protection, helping to prevent outbreaks, protect vulnerable populations, and reduce the burden on healthcare systems.
As with any medical decision, it’s important to consult with a healthcare provider to determine whether the monkeypox vaccine is right for you. By staying informed and making educated choices, you can help protect yourself and those around you from the risks associated with monkeypox.
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